Eczema and psoriasis – the difference. Eczema and psoriasis are frustrating skin conditions that can easily be confused with one another, especially by an untrained eye. These conditions might appear very similar at first, but with a closer look you will discover that they are not quite the same. To differentiate between eczema and psoriasis, it can help to learn their different symptoms and underlying causes. While we will be exploring both of these conditions, let’s start with a little background on eczema.